Diverse tissue expression of rat alpha 2-adrenergic receptor genes.

Alpha-2C Adrenergic Receptor Expression in Rat Caudal Tail Arteries

Expression of multiple alpha 2-adrenergic receptor messenger RNA species in rat tissues.

We used a human platelet alpha 2-adrenergic receptor probe to study the tissue distribution and messenger RNA (mRNA) forms of the rat alpha 2-adrenergic receptor. Under stringent conditions of hybridization and washing, we detected an mRNA species of 3.8 kb. The abundance of this form follows the order spleen, kidney, brain stem and cortex, and skeletal muscle and lung and is consistent with th...

Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat

Introduction: Anxiety is among the most common and treatable mental disorders. Adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid CB1 receptor antagonist (AM251) i...

Renal alpha-adrenergic receptor abnormality in the spontaneously hypertensive rat.

Activation of renal alpha-adrenergic receptors induces vasoconstriction, proximal tubular reabsorption of sodium, and inhibition of renal release. Excesses of these effects are present in varying degrees in animal models of, and in patients with, "essential" hypertension. Since essential hypertension is genetically determined, we sought abnormalities of renal alpha-adrenergic receptors in the O...

Mechanism of down-regulation of alpha-2 adrenergic receptor subtypes.

Long-term exposure to agonist down-regulates receptor expression for many G protein-coupled receptors. This decrease in receptor density could occur through either an increase in receptor degradation or a decrease in receptor synthesis. We studied the mechanism of down-regulation of the alpha-2A and alpha-2B adrenergic receptor subtypes transfected into the Chinese hamster ovary cell line as we...